New publications

HP1 beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs

Stixova, L., Sehnalova, P., Legartova, S., Suchankova, J., Hruskova, T., Kozubek, S., Sorokin, DV., Matula, P., Raska, I., Kovarik, A., Fulnecek, J., Bartova, E.

The stability of DNA intrastrand cross-links of antitumor transplatin derivative containing non-bulky methylamine ligands

Frybortova, M., Novakova, O., Brabec, V.

Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells

Pracharova, J., Zerzankova, L., Stepankova, J., Novakova, O., Farrer, NJ., Sadler, PJ., Brabec, V., Kasparkova, J.

Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication

Andrysik, Z., Prochazkova, J., Kabatkova, M., Umannova, L., Simeckova, P., Kohoutek, J., Kozubik, A., Machala, M., Vondracek, J.

Effect of His(6)-tagging of anterior gradient 2 protein on its electro-oxidation

Ostatna, V., Vargova, V., Hrstka, R., Durech, M., Vojtesek, B., Palecek, E.
Further publications

Selected results

Farmakologická stimulace ionizujícím zářením poškozené krvetvorby

Ozáření masivními dávkami ionizujícího záření, k jakému může dojít např. při haváriích jaderných zařízení nebo v důsledku teroristického zneužití zdrojů radiace, vede k vážným, často smrtelným následkům. 

Komplexy šestimocného osmia jako nástroje pro specifické značení cukerných zbytků v biopolymerech

In the area of electroactive labeling of natural polysaccharides this work opens new possibilities for the analysis of glycoproteins or other biomolecules possessing sugar moieties.

Sequencing of telomeres in onion

Twenty years old challenge - unknown telomeric sequence in onion and garlic from genus Allium, plants with large genomes and relatively low chromosomal numbers was solved. New ″onion″ motif, (CTCGGTTATGGG)n, is the longest and the most divergent known plant telomere variant so far.

Novel strategies of labeled nucleic acids construction and their application in electrochemical DNA sensing

Collaboration with the group of M. Hocek at the IOCB ASCR in Prague resulted in development of novel facile techniques of enzymatic construction of modified nucleic acids.

Electroactive labeling of DNA and PNA by osmium tetroxide complexes

The labeling reaction can be performed in any biochemical or biological laboratory without any special requirements for equipment or expertise.

Further results