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Virtuální prohlídka Biofyzikálního ústavu AV ČR


Gratulace Soni Legartové

Ředitelka BFÚ srdečně gratuluje Soni Legartové k získání Prémie Otto Wichterleho

New publications

Walking of antitumor bifunctional trinuclear Pt-II complex on double-helical DNA

Malina, J., Kasparkova, J., Farrell, NP., Brabec, V.

Possible mechanisms responsible for absence of a retrotransposon family on a plant Y chromosome

Kubat, Z., Zluvova, J., Vogel, I., Kovacova, V., Cermak, T., Cegan, R., Hobza, R., Vyskot, B., Kejnovsky, E.

The unique role of dietary L-arginine in the acceleration of peritoneal macrophage sensitivity to bacterial endotoxin

Pekarova, M., Kubala, L., Martiskova, H., Papezikova, I., Kralova, S., Baldus, S., Klinke, A., Kuchta, R., Kadlec, J., Kuchtova, Z., Kolarova, H., Lojek, A.

High-energy chemistry of formamide: A unified mechanism of nucleobase formation

Ferus, M., Nesvorny, D., Sponer, J., Kubelik, P., Michalcikova, R., Shestivska, V., Sponer, JE., Civis, S.

Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition

Ambrozova, G., Fidlerova, T., Verescakova, H., Koudelka, A., Rudolph, TK., Woodcock, SR., Freeman, BA., Kubala, L., Pekarova, M.
Further publications

Selected results

Novel strategies of labeled nucleic acids construction and their application in electrochemical DNA sensing

Collaboration with the group of M. Hocek at the IOCB ASCR in Prague resulted in development of novel facile techniques of enzymatic construction of modified nucleic acids.

Farmakologická stimulace ionizujícím zářením poškozené krvetvorby

Ozáření masivními dávkami ionizujícího záření, k jakému může dojít např. při haváriích jaderných zařízení nebo v důsledku teroristického zneužití zdrojů radiace, vede k vážným, často smrtelným následkům. 

Electroactive labeling of DNA and PNA by osmium tetroxide complexes

The labeling reaction can be performed in any biochemical or biological laboratory without any special requirements for equipment or expertise.

Osmium tetroxide, 2,2'-bipyridine (Os,bipy): Electroactive marker for probing accessibility of tryptophan residues in proteins.

Os,bipy forms at physiological conditions electroactive covalent adducts with tryptophan residues. 

Unfolding/denaturation and aggregation of proteins viewed by electrochemical methods

Pioneering work of the group headed by prof. E. Paleček in the field of electrochemical analysis of proteins based on their electrocatalytic activity giving rise to “peak H”.

Further results